A retrospective review on importance and various preparation of low molecular weight heparin for cardio vascular diseases
نویسندگان
چکیده
Low-molecular-weight heparin (LMWH) are most importantly used in the clinical practice for cardio vascular diseases from 1990. The LMWH was a sulfated polysaccharide obtained animal sources and some natural especially marine sources. actual anticoagulant has molecular weight about 25000 Daltons which have bleeding as side effect cardiovascular diseases. prepared by enzymatic or chemical hydrolysis length of chain is reduced also same manner below 10000 Daltons. So, it main advantage to reduce eliminated through renal not given patients with dysfunction. product still trials order its effects. commercial preparation concentrated killing them lungs, intestine etc prepare heparin. Here alternate discussed animal. This review summarizes importance, difference between LMWH, mechanism, preparation, products, sources, Enzymatic degradation shrimp species, Preparation LMW chemically modified Fractions, Chromatography separation Heparin this review.
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ژورنال
عنوان ژورنال: International journal of pharmaceutical chemistry and analysis
سال: 2023
ISSN: ['2394-2789', '2394-2797']
DOI: https://doi.org/10.18231/j.ijpca.2022.034